• Neurology · Jan 2004

    Case Reports

    Reversible language regression as an adverse effect of topiramate treatment in children.

    • Varda Gross-Tsur and Ruth S Shalev.
    • Neuropediatric Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
    • Neurology. 2004 Jan 27;62(2):299-300.

    AbstractProfound language regression developed in three children with epilepsy 4 to 28 weeks after beginning topiramate (TPM). TPM was administered as an adjunctive antiepileptic drug at doses of 2.5 to 6.0 mg/kg/day. Language functions recovered while TPM was being reduced in dose or stopped.

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