• Int J Clin Pharmacol Ther Toxicol · Apr 1992

    "Train-of-four" fade during clinical nondepolarizing neuromuscular block.

    • L Gyermek and N Berman.
    • Department of Anesthesiology, Harbor-UCLA Medical Center, Torrance 90509.
    • Int J Clin Pharmacol Ther Toxicol. 1992 Apr 1;30(4):122-7.

    UnlabelledPrevious clinical studies on the train-of-four (TOF) fade have used different recording techniques, anesthesia agents and muscles for measurement, thus comparison of the results has become difficult. On 49 surgical patients divided into 6 groups, we compared: 1) The TOF fade ratios (T4/T1) produced by d-tubocurarine (dTc), pancuronium (P), atracurium (A), and vecuronium (V) and 2) the influence of previously given suxamethonium on TOF ratios (dTc and P). Neuromuscular block (NMB) was monitored simultaneously by electromyography (EMG) and by mechanomyography (MMG). Differences between the TOF fade ratios of different groups were determined and statistically analyzed by ANOVA of repeated measures, 1) at onset, as compared to spontaneous recovery with the same agent, 2) between NMB agents at (a) onset and (b) during recovery.ResultsTOF fade was significantly more pronounced during spontaneous recovery than during onset of NMB: a) with all NMB agents, b) with both EMG and MMG responses, with bolus dose administration of the agents, c) the degrees of TOF fade significantly differed between NMB agents during onset, d) the degrees of TOF fade (MMG) were more pronounced during onset when the agents were given in incremental doses following succinylcholine as compared to degrees of fade following single bolus doses in the absence of succinylcholine. During recovery, there was also difference in the TOF fade ratios among the agents: dTc and P produced more fade than A and V.(ABSTRACT TRUNCATED AT 250 WORDS)

      Pubmed     Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…