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Pharmacol. Biochem. Behav. · Jun 1996
Randomized Controlled Trial Clinical TrialLack of acute tolerance development to the subjective, cognitive, and psychomotor effects of nitrous oxide in healthy volunteers.
- S Yajnik, J P Zacny, C J Young, J L Lichtor, G Rupani, J M Klafta, D W Coalson, and J L Apfelbaum.
- Department of Anesthesia and Critical Care, University of Chicago, Pritzker School of Medicine, IL 60637, USA.
- Pharmacol. Biochem. Behav. 1996 Jun 1;54(2):501-8.
AbstractA crossover, double-blind trial was conducted using eleven healthy volunteers to determine whether and the degree to which acute drug tolerance occurred to the subjective, cognitive, and psychomotor effects of a range of subanesthetic nitrous oxide doses (0, 10, 20, 30, and 40%). There was little evidence of acute drug tolerance to the subjective measures or to the cognitive/psychomotor impairing effects of nitrous oxide at any of the concentrations tested over the course of the 120-min inhalation.
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