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Support Care Cancer · Jan 2007
Review Case ReportsThe emerging role of cannabinoid neuromodulators in symptom management.
- Mellar Davis, Vincent Maida, Paul Daeninck, and Joseph Pergolizzi.
- The Harry R. Horvitz Center for Palliative Medicine, Cleveland Clinic, Cleveland, OH 44195, USA. davism6@ccf.org
- Support Care Cancer. 2007 Jan 1;15(1):63-71.
IntroductionThe cannabinoids nabilone (Cesamet) and dronabinol (Marinol) are indicated for the management of chemotherapy-induced nausea and vomiting (CINV) in cancer patients who have failed to respond adequately to conventional antiemetic therapy.DiscussionThe endocannabinoid (CB) system interacts with numerous other systems and pharmaceutical cannabinoids target ubiquitous CB1 and CB2 receptors in the central nervous system and periphery, relieving nausea and vomiting and pain.SummaryThe benefits of this novel class of medications in cancer may extend beyond CINV, as indicated by data from preclinical studies and animal models.
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