• Cephalalgia · Jan 2015

    Randomized Controlled Trial

    Occipital nerve stimulation for chronic migraine: a randomized trial on subthreshold stimulation.

    • P J Slotty, G Bara, L Kowatz, A Gendolla, C Wille, S Schu, and J Vesper.
    • Department of Functional Neurosurgery and Stereotaxy, Neurosurgical Clinic, Heinrich-Heine University Düsseldorf, Germany slotty@hhu.de.
    • Cephalalgia. 2015 Jan 1;35(1):73-8.

    IntroductionOccipital nerve stimulation (ONS) may provide pain relief in migraine patients. In this double-blinded trial we investigated the significance of paresthesia and possible placebo effects.MethodsPatients already treated with ONS reporting stable treatment effect were included. "Effective stimulation," "subthreshold stimulation" and "no stimulation" were compared. Patients cycled through all three treatment groups. Outcome was measured using the visual analog scale (VAS) for pain, McGill Pain Questionnaire and SF-36.ResultsEight patients were included, mean preoperative VAS was 8.20 ± 1.22. A significant improvement in pain was observed in favor of suprathreshold stimulation compared to subthreshold stimulation (1.98 ± 1.56 vs 5.65 ± 2.11). Pain also significantly improved under subthreshold stimulation compared to no stimulation (5.65 ± 2.11 vs 8.45 ± 0.99). No changes in SF-36 were observed.ConclusionsParesthesia is not required to achieve pain reduction but suprathreshold stimulation yields better results, underlining the significance of stimulation parameter customization.© International Headache Society 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

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