• Blood Coagul. Fibrinolysis · Jul 2003

    Reversal of the International Normalized Ratio with recombinant activated factor VII in central nervous system bleeding during warfarin thromboprophylaxis: clinical and biochemical aspects.

    • Benny Sørensen, Peter Johansen, Gitte L Nielsen, Jens C Sørensen, and Jørgen Ingerslev.
    • Center for Haemophilia and Thrombosis, Department of Clinical Immunology, Aarhus University Hospital, Skejby Sygehus, Denmark.
    • Blood Coagul. Fibrinolysis. 2003 Jul 1;14(5):469-77.

    AbstractMajor bleeding is a frequent and hazardous complication associated with thromboprophylaxis using vitamin-K antagonists (VKA). Suggested regimens for control of highly elevated International Normalized Ratio (INR) and hemorrhagic events during VKA treatment include administration of vitamin K, infusion of fresh frozen plasma (FFP) or a prothrombin complex concentrate (PCC). In contrast, this communication present the first report on the efficacious use of recombinant factor VIIa (rFVIIa) as additional therapy in seven patients presenting with central nervous system (CNS) bleeding emergencies. Pre-treatment INRs ranged from 1.7 to 6.6, and 10 min after a single dose of rFVIIa (10-40 microg/kg) all INRs were

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