• Takeshi Hiramatsu, Kazuyoshi Nakanishi, Shinpei Yoshimura, Atsuo Yoshino, Nobuo Adachi, Yasumasa Okamoto, Shigeto Yamawaki, and Mitsuo Ochi.
• Department of Orthopaedic Surgery, Graduate School of Biomedical & Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan. Electronic address: t.hiramatsu@enjoy.ne.jp.
• Neurosci. Lett. 2014 Oct 3;581:109-14.

AbstractFunctional MRI (fMRI) studies have been used to investigate how the brain processes noxious stimuli in osteoarthritis (OA) and to identify the cortical location of pain perception. However, no consensus has been reached regarding brain activity associated with pain-induced conditions in OA patients. We examined cerebral responses using intra-epidermal electrical stimulation of the . knee in knee OA patients. To replicate the pain of knee OA in terms of predictability, acute pain generated by electrical stimulation was provided simultaneously with displayed images in this study. We used fMRI to identify differences in response between healthy subjects and knee OA patients and explored the modulating cortico-subcortical and cortico-cortical pathways using psychophysiological interaction (PPI) analysis. Our results show that chronic pain results in a different brain activation profile in the DLPFC and the pain matrix in knee OA patients. Abnormal brain connectivity between the DLPFC and the pain matrix is induced by chronic pain in knee OA patients.Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

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