• Gabriele Centini, Andrea Calonaci, Lucia Lazzeri, Claudia Tosti, Caterina Palomba, Rosa Puzzutiello, Stefano Luisi, Felice Petraglia, and Errico Zupi.
• Obstetrics and Gynecology, Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy.
• J Minim Invasive Gynecol. 2015 Feb 1;22(2):193-8.

Study ObjectiveTo compare parenterally administered moderate sedation and paracervical block versus general anesthesia during day-case operative hysteroscopy for polypectomy in terms of patients' postoperative pain perception, operating time, and postoperative drug administration.DesignA pilot study (Canadian Task Force classification I).SettingA university hospital.PatientsWomen undergoing hysteroscopic polypectomy procedures (N = 56).InterventionsHysteroscopic polypectomy with general anesthesia or moderate parenteral sedation and paracervical block.Measurements And Main ResultsThe patients were divided into 2 groups: 26 underwent general anesthesia (group 1), and 30 were submitted to moderate parenteral sedation and a paracervical block (group 2). General anesthesia was induced with the laryngeal mask airway with propofol (1% 1-2.5 mg/kg) and fentanyl (1-2 μg/kg) and maintained with an infusion of propofol (2% 3-5 mg/kg/h). After the procedure, patients in the general anesthesia group received postoperative analgesic medication with paracetamol (20 mg/kg) and ketorolac (0.6 mg/kg) or tramadol (2-3 mg/kg). The group receiving moderate parenterally sedation and a paracervical block received a paracervical block with mepivacaine (1% 10 mL) and lidocaine (2% 10 mL) and received fentanyl (1 μg/kg) and propofol (1% 1-3 mg/kg/h) maintaining spontaneous breathing. A blind observer recorded the operative time and the discomfort of patients using a 4-step scale (0-3). The postoperative pain assessment was performed 3 hours after the procedure with a self-administered validated tool, the Brief Pain Inventory. We found that women receiving moderate parenteral sedation and a paracervical block perceived significantly less pain in daily activity (p < .001), walking (p < .001), daily work (p < .001), relations with others (p = .007), sleep (p < .001), and pain contrasting enjoyment of life (p < .001). The total amount of time spent in the operating room in group 2 was significantly lower than in group 1 (p < .014).ConclusionModerate sedation plus a paracervical block for operative hysteroscopy is associated with reduced pain perception and a shorter operative time.Copyright © 2015 AAGL. Published by Elsevier Inc. All rights reserved.

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