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American family physician · Dec 1990
Comparative StudyControversies in the treatment of streptococcal pharyngitis.
- M E Pichichero.
- University of Rochester School of Medicine and Dentistry, New York.
- Am Fam Physician. 1990 Dec 1;42(6):1567-76.
AbstractAn increasing number of cases of sore throat caused by group A beta-hemolytic streptococci occur with concomitant colonization by organisms that may "protect" the streptococci through beta-lactamase inactivation of penicillin at the site of infection. The failure of penicillin to eradicate many of these bacteria, which include Staphylococcus aureus, Haemophilus influenzae, Moraxella (Branhamella) catarrhalis and a multitude of pharyngeal anaerobes, may help to explain why penicillin is sometimes ineffective for acute and recurrent group A streptococcal infections. Therapeutic alternatives currently include cephalosporins, erythromycin, rifampin combined with penicillin, amoxicillin/clavulanate potassium and others.
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