• Mohammad Irfan Akhtar, Mohammad Saleem, and Jawad Zaheer.
• Anaesthesia Department, Aga Khan University Hospital, Karachi.
• J Pak Med Assoc. 2009 Jun 1;59(6):385-8.

ObjectiveTo compare the analgesic efficacy of Bupivacaine 0.25% wound infiltration with Ketorolac incisional infiltration in relieving postoperative pain for first twenty-four hours.MethodologyAnalytical, interventional and comparative study was performed on seventy patients, of both sexes, with varied age groups. Patients underwent minor and moderate surgeries, confined to American Society of Anaesthesiologist ASA category 1-II. Patients were selected by convenience sampling and were divided into two groups i.e. Group I and Group II. Group-I comprised of thirty five patients and were infiltrated with Bupivacaine 0.25% at wound margins postoperatively. Group-II also comprised of thirty-five patients and were infiltrated with Ketorolac at wound margins 60 mg postoperatively.ResultsBupivacaine 0.25% wound infiltration had onset of action within 4 +/- 2 minutes. Percentage pain relief was 80% in minor surgeries and 60% in moderate surgeries. Duration of action lasted for 8 +/- 2 hours regarding minor surgeries while it was 6 +/- 1 hours for moderate surgeries. Ketorolac incisional infiltration had onset of analgesic action within 10 +/- 5 minutes. Duration of action lasted for 6 +/- 1 hours regarding minor surgeries while it was 4 +/- 2 hours regarding moderate surgeries. Percentage pain relief was 60% in minor surgeries and 50% in moderate surgeries.ConclusionWound infiltration with Bupivacaine 0.25% was better for postoperative pain relief in comparison with Ketorolac regarding percentage pain relief, onset and duration of action.

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