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Leukemia & lymphoma · Feb 2014
ReviewIbrutinib in chronic lymphocytic leukemia and B cell malignancies.
- Jennifer R Brown.
- Director, CLL Center, Department of Medical Oncology, Dana-Farber Cancer Institute , Boston, MA , USA , and Department of Medicine, Harvard Medical School , Boston, MA , USA.
- Leuk. Lymphoma. 2014 Feb 1;55(2):263-9.
AbstractRecent clinical data suggest remarkable activity of ibrutinib, the first-in-class covalent inhibitor of Bruton's tyrosine kinase (BTK), in chronic lymphocytic leukemia (CLL), as well as excellent activity in other B cell malignancies, including in particular mantle cell lymphoma and Waldenstrom macroglobulinemia. This review evaluates the data from ongoing clinical and correlative studies of ibrutinib in B cell malignancies with a particular focus on CLL, and considers these data in the context of other B cell receptor pathway inhibitors.
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