• Quintino Moura Dias, João Walter Souza Silveira, Gláucia Melo Reis, Karina Abdo Costa, Ana Carolina Rossaneis, Rafael Sobrano Fais, and Wiliam Alves Prado.
• Department of Pharmacology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, São Paulo 14049–900, Brazil.
• Life Sci. 2012 Oct 29;91(17-18):837-42.

AimThis study evaluates the contribution of inhibitory pain pathways that descend to the spinal cord through the dorsolateral funiculus (DLF) on the effect of intrathecal gabapentin against spinal nerve ligation (SNL)-induced behavioral hypersensitivity to mechanical stimulation in rats.Main MethodRats were submitted to a sham or complete ligation of the right L5 and L6 spinal nerves and a sham or complete DLF lesion. Next, the changes induced by intrathecal administration of gabapentin on the paw withdrawal threshold of rats to mechanical stimulation were evaluated electronically.Key FindingsIntrathecal gabapentin (200μg/5μl) that was injected 2 or 7days after surgery fully inhibited the SNL-induced behavioral hypersensitivity to mechanical stimulation in sham DLF-lesioned rats; gabapentin was effective against the SNL-induced behavioral hypersensitivity to mechanical stimulation also in DLF-lesioned rats.SignificanceThe effect of intrathecally administered gabapentin against SNL-induced behavioral hypersensitivity to mechanical stimulation in rats does not depend on the activation of nerve fibers that descend to the spinal cord via the DLF.Copyright © 2012 Elsevier Inc. All rights reserved.

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