• B F Dear, L G Staples, M D Terides, E Karin, J Zou, L Johnston, M Gandy, V J Fogliati, B M Wootton, P M McEvoy, and N Titov.
• eCentreClinic, Department of Psychology, Macquarie University, Sydney, Australia. Electronic address: blake.dear@mq.edu.au.
• J Anxiety Disord. 2015 Dec 1; 36: 63-77.

AbstractGeneralized anxiety disorder (GAD) can be treated effectively with either disorder-specific cognitive behavior therapy (DS-CBT) or transdiagnostic CBT (TD-CBT). The relative benefits of DS-CBT and TD-CBT for GAD and the relative benefits of delivering treatment in clinician guided (CG-CBT) and self-guided (SG-CBT) formats have not been examined. Participants with GAD (n=338) were randomly allocated to receive an internet-delivered TD-CBT or DS-CBT intervention delivered in either CG-CBT or SG-CBT formats. Large reductions in symptoms of GAD (Cohen's d ≥ 1.48; avg. reduction ≥ 50%) and comorbid major depressive disorder (Cohen's d ≥ 1.64; avg. reduction ≥ 45%), social anxiety disorder (Cohen's d ≥ 0.80; avg. reduction ≥ 29%) and panic disorder (Cohen's d ≥ 0.55; avg. reduction ≥ 33%) were found across the conditions. No substantive differences were observed between DS-CBT and TD-CBT or CG-CBT and SG-CBT, highlighting the public health potential of carefully developed TD-CBT and SG-CBT.Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

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