• Youngsoon Kim, So Yeon Kim, Jong Seok Lee, Hee Jung Kong, and Dong Woo Han.
• Department of Anesthesiology and Pain Medicine and Anesthesia and Pain Research Institute, Gangnam Severance Hospital, 211 Eonju-ro, Gangnam-gu, Seoul 135-720, Korea. hanesth@yuhs.ac.
• Yonsei Med. J. 2014 Mar 1; 55 (2): 517-22.

PurposeThe aim of this study is to evaluate the effect of dexmedetomidine on corrected QT (QTc) and Tp-e intervals in patients undergoing spinal anesthesia.Materials And MethodsWe studied 50 patients who were scheduled to undergo spinal anesthesia before orthopedic surgeries. Patients were allocated to receive either an infusion of dexmedetomidine or normal saline after spinal anesthesia.ResultsQTc intervals were significantly prolonged after spinal anesthesia, and the prolonged QTc interval returned to baseline values 10 minutes after either normal saline or dexmedetomidine administration in both groups. The QTc interval values after dexmedetomidine administration were significantly shorter compared to the QTc interval values just before dexmedetomidine administration.ConclusionDexmedetomidine could promote the return of a prolonged QTc interval induced by spinal anesthesia and might be helpful in patients who have a prolonged QTc interval.

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