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- Olivier Sitbon and Nicholasw Morrell.
- Université Paris-Sud, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France.
- Eur Respir Rev. 2012 Dec 1;21(126):321-7.
AbstractIt is well established that the endothelin, nitric oxide and prostacyclin pathways play an important role in the development of pulmonary arterial hypertension (PAH). Indeed, the therapeutic options currently available for the management of PAH all act on one of these mechanistic pathways. However, this is an exciting time for both clinicians and scientists, as increased understanding of the mechanisms involved in the pathogenesis and progression of PAH has resulted in the development of a number of novel therapeutic options. This article highlights how the introduction of new compounds such as macitentan, riociguat and selexipag, which act on the endothelin, nitric oxide and prostacyclin pathways, respectively, have the potential to further improve the prognosis for patients with PAH.
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