• Craig A Reickert, Preston B Rich, Stefania Crotti, Simon A Mahler, Samir S Awad, William R Lynch, Kent J Johnson, and Ronald B Hirschl.
• Department of Surgery, University of Michigan Medical Center, Ann Arbor, USA.
• Crit. Care Med. 2002 Jan 1;30(1):182-9.

ObjectiveTo examine the isolated and combined effects of positive end-expiratory pressure (PEEP) and partial liquid ventilation (PLV) on the development of ventilator-induced lung injury in an ovine model.DesignProspective controlled animal study.SettingUniversity-based cardiovascular animal physiology laboratory.SubjectsThirty-eight anesthetized supine sheep weighing 22.3 +/- 2.2 kg.InterventionsAnimals were ventilated for 6 hrs (respiratory rate, 15; FIO2, 1.0, inspiratory/expiratory ratio, 1:1) with one of five pressure-controlled strategies, expressed as peak inspiratory pressure (PIP)/PEEP: low-PIP, 25/5 cm H2O (n = 8); high-PIP, 50/5 cm H2O (n = 8); high-PIP-PLV, 50/5 cm H2O-PLV (n = 8); high-PEEP, 50/20 cm H2O (n = 7); and high-PEEP-PLV, 50/20 cm H2O-PLV (n = 7).Measurements And Main ResultsCompared with the low-PIP control, high-PIP ventilation increased airleak, shunt, histologic evidence of lung injury, neutrophil infiltrates, and wet lung weight. Maintaining PEEP at 20 cm H2O or adding PLV reduced the development of physiologic shunt and dependent histologic injury indexes. Neither higher PEEP nor PLV reduced the high incidence of barotrauma observed in high-PIP animals.ConclusionsWe conclude that application of PLV or PEEP at 20 cm H2O may improve gas exchange and afford lung protection from ventilator-induced lung injury during high-pressure mechanical ventilation in this model.

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