• Med Sci Sports Exerc · Jul 2008

    Randomized Controlled Trial

    Effects of acute salbutamol inhalation on quadriceps force and fatigability.

    • Nicolas Decorte, Samuel Verges, Patrice Flore, Michel Guinot, and Bernard Wuyam.
    • REX-S Laboratory, Joseph Fourier University and UF Exercise Research, Grenoble University Hospital, Grenoble, FRANCE.
    • Med Sci Sports Exerc. 2008 Jul 1;40(7):1220-7.

    IntroductionOral beta2-agonist administration improves muscle function in persons without asthma. We performed a double-blind, randomized, controlled crossover study to assess whether acute inhaled salbutamol administration improves muscle strength and fatigability in healthy moderately trained subjects.MethodsQuadriceps muscle strength was measured during maximal voluntary contraction (MVC) and femoral nerve magnetic stimulation (potentiated single twitch, TwQpeak) before and after (i) a maximal incremental cycling test (n = 10) and (ii) 50 maximal isometric one-leg extensions (n = 9). Each exercise test was performed on three occasions, after salbutamol (200 and 800 microg) or placebo inhalation.ResultsBefore exercise, treatments had no significant effect on MVC [(placebo) 597 +/- 146 N vs (200 microg) 629 +/- 151 N vs (800 microg) 610 +/- 148 N] and TwQpeak [(placebo) 215 +/- 83 N vs (200 microg) 227 +/- 69 N vs (800 microg) 250 +/- 84 N]. Maximal power during cycling and maximal force during leg extensions did not differ between treatments. Treatments had no effect on MVC and TwQpeak reductions at 30 min [MVC: (placebo) -8 +/- 9% vs (200 microg) -9 +/- 7% vs (800 microg) -8 +/- 5%; TwQpeak: (placebo) -29 +/- 13% vs (200 microg) -23 +/- 15% vs (800 microg) -20 +/- 8%] and 60 min [MVC: (placebo) -12 +/- 17% vs (200 microg) -6 +/- 9% vs (800 microg) -8 +/- 8%; TwQpeak: (placebo) -20 +/- 21% vs (200 microg) -19 +/- 23% vs (800 microg) -8 +/- 7%] after cycling. Similarly, reductions in MVC and TwQpeak were not significantly different between treatments at 30 [MVC: (placebo) -11 +/- 9% vs (200 microg) -12 +/- 7% vs (800 microg) -8+/- 16%; TwQpeak: (placebo) -37 +/- 12% vs (200 microg) -33 +/- 20% vs (800 microg) -32 +/- 16%] and 60 min [MVC: (placebo) -10 +/- 11% vs (200microg) -11 +/- 6% vs (800 microg) -8 +/- 20%; TwQpeak: (placebo) -30 +/- 11% vs (200 microg) -28 +/- 24% vs (800 microg) -27 +/- 15%] after leg extensions. Treatments did not modify maximal voluntary activation at any time of the protocol.ConclusionAcute therapeutic or supratherapeutic doses of inhaled salbutamol have no effect on quadriceps strength, fatigue, and recovery in men without asthma.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…