• Beijing Da Xue Xue Bao · Apr 2009

    Review

    [ATP-sensitive potassium channel and its cardiovascular protection effects].

    • Rong-yuan Zhang, Hong-fang Jin, Chao-shu Tang, and Jun-bao DU.
    • Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.
    • Beijing Da Xue Xue Bao. 2009 Apr 18;41(2):245-8.

    AbstractATP-sensitive potassium channel(K(ATP)) consists of a 4.4 complex of an inwardly rectifying Kir6.x pore plus a sulfonylurea receptor, which is an ATP-binding cassette transporter. K(ATP) has been indentified in a variety of tissues and recognized as an important drug target. It connects cell metabolism with cell electric activity. K(ATP) has been proposed to play protective roles during heart failure, arrhythmia, myocardial infarction, stress, myocardial ischemia and hypertension. In this review, a summary of K(ATP) is presented with molecular structure, localization, regulation, cardiovascular protective effect and its mechanisms.

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