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Annals of plastic surgery · Jun 2009
The effect of enalapril on skin flap viability is independent of angiotensin II AT1 receptors.
- Hamidreza Pazoki-Toroudi, Marjan Ajami, Rouhollah Habibey, Ehsan Hajiaboli, and Alireza Firooz.
- Department of Physiology, Iran University of Medical Sciences, Tehran, Iran. pazoki49@gmail.com
- Ann Plast Surg. 2009 Jun 1;62(6):699-702.
AbstractRandom pattern skin flaps are still widely used in plastic surgery. However, necrosis in the distal portion resulting from ischemia is a serious problem, increasing the cost of treatment and hospitalization. To enhance skin flap viability, a variety of pharmacologic agents have been intensively investigated. The aim of this study was to assess the effect of enalapril (an angiotensin-converting enzyme inhibitor) and losartan (an angiotensin receptor blocker) in skin flap viability. Male rats of 200 to 250 g were used. Different doses of enalapril (5, 20, and 50 mg/kg) and losartan (5 mg/kg) were administrated 30 minutes prior to elevate the flap. Flap survival area was evaluated on the seventh postoperative day. Enalapril improved survival area in a dose-dependent manner, but losartan failed to improve survival area, which suggested that the effect of enalapril was not mediated through AT1 receptors.
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