• American heart journal · May 2010

    Duration of red cell storage before transfusion and in-hospital mortality.

    • John W Eikelboom, Richard J Cook, Yang Liu, and Nancy M Heddle.
    • Department of Medicine, McMaster University, Ontario, Canada. eikelbj@mcmaster.ca
    • Am. Heart J. 2010 May 1;159(5):737-743.e1.

    BackgroundRed cell transfusions are lifesaving in severely anemic or acutely bleeding patients but may be associated with an increased risk of cardiovascular events in critically ill patients. The objective of the study was to examine the association between duration of pretransfusion storage of red cells and in-hospital mortality.MethodsWe used multivariable Cox regression modeling with time-dependent stratification to assess the effect of age of transfused red blood cells on risk of in-hospital mortality in a registry of consecutive patients admitted to an acute care facility with a major diagnosis of cardiovascular disease.ResultsFour thousand nine hundred thirty-three consecutive patients with a major diagnosis of cardiovascular disease admitted to acute care facilities in Hamilton, Canada, received 21,435 units of red cells. The median number of units received was 3 (interquartile range 2-5), and the median age of transfused blood was 17 (interquartile range 13-22) days. After adjustment for demographics, clinical characteristics, and time-dependent covariates and stratification by the number of units transfused, the relative risk for death was 1.02 for every 1-day increase in maximum age of blood. The adjusted relative risk for death increased with each increasing quartile of maximum age of blood, with patients in the highest quartile having a relative risk for death of 1.48 (95% CI 1.07-2.05) compared with those in the lowest (reference) quartile.ConclusionsIn hospitalized patients with a major diagnosis of cardiovascular disease, there is a modest independent association between increasing duration of storage of red cells and risk of in-hospital mortality that appears to be continuous and graded.2010 Mosby, Inc. All rights reserved.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…