• Curr. Opin. Neurobiol. · Jun 2002

    Review

    Sleep, feeding, and neuropeptides: roles of orexins and orexin receptors.

    • Michihiro Mieda and Masashi Yanagisawa.
    • Howard Hughes Medical Institute, Department of Molecular Genetics, University of Texas, Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9050, USA.
    • Curr. Opin. Neurobiol. 2002 Jun 1;12(3):339-45.

    AbstractRecent studies using molecular genetics in mice and dogs, as well as histopathological analyses of human disease, have come to the same conclusion: the human sleep disorder narcolepsy is caused by failure of signaling mediated by orexin (hypocretin) neuropeptides. These and other findings strongly suggest that the orexin system plays a critical role in sleep/wake regulation. In addition, the orexin system may link energy homeostasis to the regulation of sleep/wake cycles.

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