• Clin. Appl. Thromb. Hemost. · Sep 2013

    Observational Study

    Efficacy of recombinant human soluble thrombomodulin in severe postpartum hemorrhage with disseminated intravascular coagulation.

    • Junichi Sugawara, Kaori Suenaga, Tetsuro Hoshiai, Takahiro Sato, Hidekazu Nishigori, Satoru Nagase, and Nobuo Yaegashi.
    • 1Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai, Japan.
    • Clin. Appl. Thromb. Hemost. 2013 Sep 1;19(5):557-61.

    ObjectiveTo investigate the efficacy of recombinant human soluble thrombomodulin (rTM) in disseminated intravascular coagulation (DIC) associated with severe postpartum hemorrhage (PPH).Patients And MethodsWe conducted a retrospective review of 36 patients with severe PPH complicated by DIC admitted to a single tertiary center. The first 26 patients were treated without rTM (control group), and the next 10 consecutive patients were treated with rTM. Clinical parameters including bleeding symptoms and coagulation indices were evaluated.ResultsBaseline characteristics, total blood loss, and transfusion requirements were similar between the 2 groups. On day 2, there was a significant difference between the 2 groups in the decrease in d-dimer level from baseline. The incidence of bleeding symptoms was decreased in the rTM group compared with the control group. No adverse events were observed in the rTM group.ConclusionRecombinant human thrombomodulin may be an effective adjunctive therapy in the management of DIC related to PPH.

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