• Anasthesiol Intensivmed Notfallmed Schmerzther · Nov 2009

    Review

    [Malignant hyperthermia--diagnostics, treatment and anaesthetic management].

    • Frank Schuster and Clemens R Müller-Reible.
    • Klinik und Poliklinik für Anästhesiologie, Universitätsklinikums Würzburg. schuster_f@klinik.uni-wuerzburg.de
    • Anasthesiol Intensivmed Notfallmed Schmerzther. 2009 Nov 1;44(11-12):758-63; quiz 764.

    AbstractIn malignant hyperthermia (MH) susceptible individuals volatile anaesthetics and the depolarizing muscle relaxant succinylcholine may induce a potentially lethal hypermetabolic syndrome of skeletal muscle due to an uncontrolled sarcoplasmic calcium release. Immediate discontinuation of triggering agents, oxygenation, correction of acidosis and electrolyte abnormalities and dantrolene application are essential for MH treatment. This article reviews the clinical symptoms of MH, the diagnostic criteria and the actual guidelines for treatment and management of anaesthesia in susceptible individuals.(c) Georg Thieme Verlag KG Stuttgart-New York.

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