• Adv Chronic Kidney Dis · May 2011

    Review

    Iodinated contrast media and the role of renal replacement therapy.

    • Steven D Weisbord and Paul M Palevsky.
    • Renal Section, Center for Health Equity Research and Promotion, VA Pittsburgh Healthcare System, PA, USA. weisbordsd@upmc.edu
    • Adv Chronic Kidney Dis. 2011 May 1;18(3):199-206.

    AbstractIodinated contrast media are among the most commonly used pharmacologic agents in medicine. Although generally highly safe, iodinated contrast media are associated with several adverse effects, most significantly the risk of acute kidney injury, particularly in patients with underlying renal dysfunction. By virtue of their pharmacokinetic characteristics, these contrast agents are efficiently cleared by hemodialysis and to a lesser extent, hemofiltration. This has led to research into the capacity for renal replacement therapies to prevent certain adverse effects of iodinated contrast. This review examines the molecular and pharmacokinetic characteristics of iodinated contrast media and critically analyzes data from past studies on the role of renal replacement therapy to prevent adverse effects of these diagnostic agents.Published by Elsevier Inc.

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