• Critical care clinics · Apr 2000

    Review

    Pharmacologic issues in the management of septic shock.

    • N Jindal, S M Hollenberg, and R P Dellinger.
    • Department of Medicine, Rush Medical College, Chicago, Illinois, USA.
    • Crit Care Clin. 2000 Apr 1; 16 (2): 233-49.

    AbstractDespite our increased understanding of the biochemistry and physiology of sepsis, the treatment of septic shock remains a challenge. Initial management of septic shock entails urgent and emergent stabilization of the patient followed by broad-spectrum, empiric antibiotic therapy. After volume resuscitation, vasopressors or inotropic therapy or both may be necessary to restore perfusion. Adjunctive therapies and monitoring strategies may be helpful in preventing complications in the intensive care setting. Additional research and clinical trials are needed to identify supportive interventions that may affect the outcome of the septic patient.

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