• Acta physiologica · Jan 2013

    Effects of Salusin-β on action potential and ionic currents in ventricular myocytes of rats.

    • An-Jing Ren, Qing Liang, Rong Wang, Hai-Yu Ji, Yi Wu, Jing-Song Shi, Li Lin, and Wen-Jun Yuan.
    • Department of Pathophysiology, Second Military Medical University, Shanghai, China. renanjing@gmail.com
    • Acta Physiol (Oxf). 2013 Jan 1;207(1):166-72.

    AimSalusin-β is a regulatory peptide that exerts negative inotropic effect on ventricular muscle, but its electrophysiological effects on ventricular myocytes are still unknown.MethodsAction potential and channel currents such as sodium current (I(N) (a) ), transient outward potassium current (I(to) ), steady-state potassium current (I(sus) ), sodium-calcium exchange current (I(N) (aCa) ) and inward rectifier potassium current (I(K) (1) ) were measured in ventricular myocytes isolated from 12 to 16 weeks rats by whole-cell voltage-clamp techniques.ResultsSalusin-β dose-dependently shortened the duration of action potential in rat ventricular myocytes. Furthermore, salusin-β significantly inhibited I(N) (aCa) and increased I(to) , but did not affect I(N) (a) , I(sus) and I(K) (1) .ConclusionThese results suggest that the effect of salusin-β on action potential may be partly attributed to a decrease in inward currents and an increase in outward currents.© 2012 The Authors Acta Physiologica © 2012 Scandinavian Physiological Society.

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