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Br J Clin Pharmacol · Oct 2009
Progenitors in motion: mechanisms of mobilization of endothelial progenitor cells.
- Lindsey Tilling, Philip Chowienczyk, and Brian Clapp.
- King's College London, London SE1 7EH, UK. lindsey.tilling@kcl.ac.uk
- Br J Clin Pharmacol. 2009 Oct 1;68(4):484-92.
AbstractEndothelial progenitor cells are a population of bone marrow-derived mononuclear cells thought to engage in endothelial repair and hence are considered potential therapeutic agents in many pathological conditions. The mechanism of their exit from the bone marrow to the circulation and damaged tissues, termed mobilization, has not been fully elucidated. Despite this, several pharmacological interventions have been shown to influence mobilization of these specialized cells. Here we review the current understanding of their mobilization.
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