• Hamostaseologie · Jan 2014

    Review

    [Pharmacological thromboprophylaxis in gynecology and obstetrics].

    • R E Scharf and M A Pestka.
    • Univ.-Prof. Dr. med. Rüdiger E. Scharf, F.A.H.A., Institut für Hämostaseologie, Hämotherapie und Transfusionsmedizin und Hemophilia Comprehensive, Care Center, Universitätsklinikum Düsseldorf, Heinrich-Heine-Universität, Moorenstraße 5, 40225 Düsseldorf, Tel. 02 11/ 811 73-44 / -45, Fax: 02 11/ 811 62 21, E-Mail: rscharf@uni-duesseldorf.de.
    • Hamostaseologie. 2014 Jan 1;34(4):277-88; quiz 289.

    AbstractVenous thromboembolism (VTE) is associated with high morbidity and mortality. Therefore, effective methods for safe thromboprophylaxis remain an ongoing challenge in daily clinical practice. This is especially true for pregnant women and patients with gynaecological malignancies. Low-molecular weight heparins continue to be agents of choice for pharmacological thromboprophylaxis postoperatively, in pregnant patients at risk, and during the puerperium. However, these drugs can cause bleeds or heparin-induced thrombocytopenia (type II). Based on recent revisions of corresponding guidelines, this article provides an overview of the current state of pharmacological thromboprophylaxis and discusses prevailing problems and unresolved issues.

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