• Antimicrob. Agents Chemother. · Nov 2008

    In vitro activity of OPT-80 tested against clinical isolates of toxin-producing Clostridium difficile.

    • James A Karlowsky, Nancy M Laing, and George G Zhanel.
    • Department of Clinical Microbiology, Health Sciences Centre, MS673C, 820 Sherbrook Street, Winnipeg, Manitoba, Canada. jkarlowsky@hsc.mb.ca
    • Antimicrob. Agents Chemother. 2008 Nov 1;52(11):4163-5.

    AbstractAgar dilution antimicrobial susceptibility testing (CLSI, M11-A7, 2007) performed for 208 toxin-producing clinical isolates of Clostridium difficile resulted in OPT-80 MICs ranging from 0.06 to 1 microg/ml, with 90% of the isolates inhibited by a concentration of 0.5 microg/ml. The in vitro activity of OPT-80 was independent of the susceptibilities of isolates to nine other antimicrobial agents.

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