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Clin. Pharmacol. Ther. · Jul 2014
CommentPatients benefit from genetics-guided coumarin anticoagulant therapy.
- A H Maitland-van der Zee, A K Daly, F Kamali, V G Manolopoulous, V G Manolopoulos, T I Verhoef, M Wadelius, A de Boer, M Pirmohamed, and EU-PACT Study Group.
- Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands.
- Clin. Pharmacol. Ther. 2014 Jul 1;96(1):15-7.
AbstractObservational studies have overwhelmingly shown that variants in the genes CYP2C9 and VKORC1 are significant determinants of individual dose of coumarin anticoagulants needed to maintain a therapeutic international normalized ratio (INR).(1) Until recently, however, few randomized clinical trials had been performed relating to the use of genetic data to predict dosing. Three sucsh clinical trials have now reported their findings.
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