• Paediatric anaesthesia · Jan 1998

    Randomized Controlled Trial Comparative Study Clinical Trial

    Comparison of granisetron and droperidol in the prevention of vomiting after strabismus surgery or tonsillectomy in children.

    • Y Fujii, Y Saitoh, H Tanaka, and H Toyooka.
    • Department of Anaesthesiology, University of Tsukuba Institute of Clinical-Medicine, Ibaraki, Japan.
    • Paediatr Anaesth. 1998 Jan 1;8(3):241-4.

    AbstractThis prospective, randomized, double-blinded study evaluated the antiemetic efficacy of granisetron and droperidol in 80 ASA physical status I children, aged 4-10 years, undergoing strabismus surgery or tonsillectomy with or without adenoidectomy. After anaesthetic induction, the patients received either granisetron (40 micrograms.kg-1, n = 40) or droperidol (50 micrograms.kg-1, n = 40) intravenously. The incidence of vomiting during the first 24h after anaesthesia was 15% and 38% after administering granisetron and droperidol, respectively (P = 0.02). The requirement for rescue antiemetic therapy for the treatment of two or more episodes of vomiting was 0% with granisetron and 18% with droperidol (P = 0.001). In conclusion, granisetron was superior to droperidol in reducing the incidence and frequency of postoperative vomiting in paediatric patients.

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