• Journal of neuro-oncology · Jun 2012

    Refining endpoints in brain tumor clinical trials.

    • Christina A Meyers, Edwin P Rock, and Howard A Fine.
    • Department of Neuro-Oncology, M.D. Anderson Cancer Center, Houston, TX, USA. cameyers53@yahoo.com
    • J. Neurooncol. 2012 Jun 1;108(2):227-30.

    AbstractAs targeted therapies advance treatment for brain tumors, standard clinical trial endpoints of survival, progression free survival and radiographic response have become insufficient to capture clinical benefit. Brain cancer is a malignancy with neurodegenerative features. In this setting prolongation of life and/or radiographic stability are less clinically meaningful if neurocognitive function substantially declines. Hence evaluation of new therapeutic strategies should routinely include periodic assessment of neurocognitive function.

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