• T Kasaba and T Inoue.
• Department of Anesthesiology, Miyazaki Medical College.
• Masui. 1997 Mar 1;46(3):321-5.

AbstractWe have investigated the effects of cervical epidural anesthesia on-phrenic nerve activity (PNA), and epidural somatosensory evoked potential (SSEP) elicited by stimulation of the radial nerve in pentobarbital anesthetized cats. PNA was suppressed significantly to 72% of control value 10 min after injection of 1% lidocaine and recovered to control value within 30 min. Following 2% lidocaine injection, PNA tended to be more suppressed than with 1% lidocaine to 57% and recovered to control value within 30 min. Peak latencies of P1, N1, P2, N2, and P3 before injection of 1% lidocaine were 1.05 (0.24), 1.20 (0.11), 1.51 (0.20), 1.56 (0.34), 2.71 (0.33) (msec (SD)), respectively. Though these latencies did not increase after injection of 1% lidocaine, injection of 2% lidocaine increased them significantly and these elevations continued for 120 min. The amplitude of N2 increased significantly after injection of 1% lidocaine and the amplitude of N2 and N2-P3 increased after injection of 2% lidocaine. These results indicate that 2% lidocaine blocked the sensory nerve and the effects continued much longer than the depression of PNA by cervical epidural anesthesia.

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