• Adam Stein, Arti Panjwani, Cristina Sison, Lisa Rosen, Radhika Chugh, Christine Metz, Matthew Bank, and Ona Bloom.
• Department of Physical Medicine and Rehabilitation, Hofstra North Shore-Long Island Jewish School of Medicine, The North Shore-Long Island Jewish Health System, Manhasset, NY, USA.
• Arch Phys Med Rehabil. 2013 Aug 1;94(8):1498-507.

ObjectiveTo test the hypothesis that the proinflammatory cytokine macrophage migration inhibitory factor (MIF) is elevated in the circulation of patients with chronic spinal cord injury (SCI) relative to uninjured subjects, and secondarily to identify additional immune mediators that are elevated in subjects with chronic SCI.DesignProspective, observational pilot study.SettingOutpatient clinic of a department of physical medicine and rehabilitation and research institute in an academic medical center.ParticipantsIndividuals with chronic (>1y from initial injury) SCI (n=22) and age- and sex-matched uninjured subjects (n=19).InterventionsNot applicable.Main Outcome MeasuresPlasma levels of MIF, as determined by a commercially available multiplex suspension immunoassay. The relationship between MIF levels and clinical/demographic variables was also examined. As a secondary outcome, we evaluated other cytokines, chemokines, and growth factors.ResultsPlasma MIF levels were significantly higher in subjects with chronic SCI than in control subjects (P<.001). Elevated MIF levels were not correlated significantly with any one clinical or demographic characteristic. Subjects with SCI also exhibited significantly higher plasma levels of monokine induced by interferon-gamma/chemokine C-X-C motif ligand 9 (P<.03), macrophage colony stimulating factor (P<.035), interleukin-3 (P<.044), and stem cell growth factor beta (SCGF-β) (P<.016). Among subjects with SCI, the levels of SCGF-β increased with the time from initial injury.ConclusionsThese data confirm the hypothesis that MIF is elevated in subjects with chronic SCI and identify additional novel immune mediators that are also elevated in these subjects. This study suggests the importance of examining the potential functional roles of MIF and other immune factors in subjects with chronic SCI.Copyright © 2013 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

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