• Zhejiang Da Xue Xue Bao Yi Xue Ban · May 2008

    Randomized Controlled Trial Comparative Study

    [Comparison of midazolam and propofol as conscious sedation in oocyte retrieval of IVE-ET].

    • Yuan-Ying Ma, Yan Shen, and Li-San Zhang.
    • The Affiliated Obstetrics and Gynecology Hospital, College of Medicine, Zhejiang University, Hangzhou 310006, China.
    • Zhejiang Da Xue Xue Bao Yi Xue Ban. 2008 May 1;37(3):304-7.

    ObjectiveTo compare the efficacy and safety of midazolam combined with fentanyl and propofol combined with fentanyl as conscious sedation in oocyte retrieval of in vitro fertilization and embryo transplantation (IVF-ET).MethodsEighty patients receiving IVE-ET were randomly divided into midazolam combined with fentanyl group (midazolam group) and propofol combined with fentanyl group (propofol group). Antalgic effects, circulation status (blood pressure, heart rate), respiration status (rate, oxygen saturation and respiration depression) during operation, nausea and vomiting, and amnestic effects after operation were compared.ResultNo differences of antalgic effects and circulation status between two groups were observed. Percentages of respiration depression,vomiting and amnesia of midazolam group were 5.0 %, 10.0 % and 25%, respectively, and those of propofol group were 25%, 27.5% and 7.5%, respectively, which had statistical significance.ConclusionAs conscious sedation, midazolam combined with fentanyl is better than propofol combined with fentanyl in oocyte retrieval of IVF-ET.

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