• Haiko Sprott, Renate E Gay, Beat A Michel, and Steffen Gay.
• Center of Experimental Rheumatology, Department of Rheumatology and Institute of Physical Medicine, University Hospital Zurich and the Center for Integrative Human Physiology (CIHP), University of Zurich, Zurich, Switzerland. haiko.sprott@usz.ch
• J Rheumatol. 2006 Dec 1;33(12):2515-8.

ObjectiveTo determine whether ibuprofen-arginine has a cyclooxygenase-independent pain modulating property in addition to its known antiinflammatory effect.MethodsPatients with chronic low back pain were randomly divided into 2 groups treated either with oral ibuprofen-arginine (400 mg) or with placebo. Blood was drawn from study subjects before, during, and after treatment and they were asked each time about the intensity of their pain. Concentrations of nitric oxide (NO) metabolites were determined.ResultsTwenty minutes after intake of ibuprofen-arginine, but not after placebo, there was a relevant and significant reduction of NO metabolites in serum. In both groups there was significant analgesic effect compared to baseline.ConclusionAn early lowering of the serum NO metabolite levels after ibuprofen-arginine administration could be detected in patients with chronic low back pain.

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