• Ann Am Thorac Soc · Mar 2015

    Review

    Mechanisms and clinical consequences of acute lung injury.

    • Vito Fanelli and V Marco Ranieri.
    • Department of Anesthesia and Critical Care, University of Turin, Turin, Italy.
    • Ann Am Thorac Soc. 2015 Mar 1;12 Suppl 1:S3-8.

    AbstractAcute respiratory distress syndrome (ARDS) was first described in 1967, and since then there have been a large number of studies addressing its pathogenesis and therapies. Despite intense research efforts, very few therapies for ARDS have been shown to be effective other than the use of lung protection strategies. The scarcity of therapeutic choices is related to the intricate pathogenesis of the syndrome and to insensitive and aspecific criteria to diagnose this profound acute respiratory failure. The aim of this paper is to summarize advances of new ARDS definitions and provide an overview of new relevant signaling pathways that mediate acute lung injury.

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