• Biomarkers · Aug 2012

    Circulating microRNAs as potential biomarkers for smoking-related interstitial fibrosis.

    • Yuchuan Huang, Ya Dai, Jie Zhang, Changguo Wang, Dongliang Li, Jingqiu Cheng, Yanrong Lu, Kuoyan Ma, Lanlan Tan, Fang Xue, and Bo Qin.
    • West China Hospital, Sichuan University, Chengdu, China. huangyuchuan1999@yahoo.com.cn
    • Biomarkers. 2012 Aug 1;17(5):435-40.

    AbstractNumerous efforts have been made to indentify reliable and predictive biomarkers to detect the early signs of smoking-induced lung disease. Using 6-month cigarette smoking in mice, we have established smoking-related interstitial fibrosis (SRIF). Microarray analyses and cytokine/chemokine biomarker measurements were made to select circulating microRNAs (miRNAs) biomarkers. We have demonstrated that specific miRNAs species (miR-125b-5p, miR-128, miR-30e, and miR-20b) were significantly changed, both in the lung tissue and in plasma, and exhibited mainstream (MS) exposure duration-dependent pathological changes in the lung. These findings suggested a potential use of specific circulating miRNAs as sensitive and informative biomarkers for smoking-induced lung disease.

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