• Jai Jai Shiva Shankar, Marlise P dos Santos, Leonardo Deus-Silva, and Cheemun Lum.
• Department of Medical Imaging, The Ottawa Hospital, Ottawa, ON, Canada.
• Neuroradiology. 2011 Feb 1;53(2):123-8.

IntroductionSeveral methods have been used to treat cerebral vasospasm, which is a major cause of morbidity and mortality in patients with aneurysmal subarachnoid hemorrhage (SAH). Here, we examined the effectiveness and safety of intra-arterial injection of milrinone for the treatment of vasospasm.MethodsConsecutive patients with angiographically confirmed vasospasm received intra-arterial milrinone between January 2006 and December 2007. The improvement in diameter of vessel (in millimeters) following treatment was assessed by paired t test for statistical significance. The angiographic improvement of supraclinoid internal carotid artery, M1 segment of middle cerebral artery, and A1 and A2 segment of anterior cerebral artery was compared with the modified Rankin score of the patients at discharge.ResultsA total of 15 milrinone treatments were performed in 14 patients (11 females and 3 males) with mean age of 52.7 years (31-68 years). There was significant angiographic improvement after milrinone therapy (p < 0.0001).ConclusionIntra-arterial milrinone was a safe and effective treatment of cerebral vasospasm following aneurysmal SAH.

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