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- George Howard.
- Department of Biostatistics, University of Alabama at Birmingham School of Public Health, Birmingham, AL 35294-0022, USA. ghoward@uab.edu
- Stroke. 2007 Feb 1;38(2 Suppl):804-8.
AbstractStatistical sciences have recently made advancements that allow improved precision or reduced sample size in clinical research studies. Herein, we review 4 of the more promising: (1) improvements in approaches for dose selection trials, (2) approaches for sample size adjustment, (3) selection of study end point and associated statistical methods, and (4) frequentist versus Bayesian statistical methods. Whereas each of these holds the opportunity for more efficient trials, each are associated with the need for more stringent assumptions or increased complexity in the interpretation of results. The opportunities for these promising approaches, and their associated "costs," are reviewed.
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