• Aase Sagen, Rolf Kaaresen, Leiv Sandvik, Inger Thune, and May Arna Risberg.
• Department of Cancer Treatment, The Norwegian Research Center for Active Rehabilitation, Oslo University Hospital, Oslo, Norway. Electronic address: aase.sagen@uus.no.
• Arch Phys Med Rehabil. 2014 May 1;95(5):875-81.

ObjectiveTo examine upper limb physical function and adverse effects after axillary lymph node dissection (ALND) and sentinel lymph node biopsy (SLNB) in patients with breast cancer to identify impairments that can inform rehabilitation strategies.DesignProspective longitudinal cohort. Upper limb measurements were studied preoperatively and 2.5 years after breast cancer treatment.SettingHospital setting.ParticipantsTwo groups of patients with early-stage primary breast cancer (N=391): the ALND surgery group (mean age, 55±10y) and the SLNB group (mean age, 57±10y).InterventionsNot applicable.Main Outcome MeasuresArm lymphedema (≥10% increased arm volume relative to control arm volume), grip strength (in kilograms), shoulder mobility, pain intensity during isometric shoulder abduction (on a 100-mm visual analog scale), and body mass index (kg/m(2)). Parametric/nonparametric tests were used for hypothesized changes and differences, and regression analysis was used for confounding factors.ResultsWe observed more adverse effects in women treated with ALND than with SLNB after 2.5 years (P<.05): arm lymphedema (17% vs 3%), grip strength reduction (12% vs 2%), and shoulder abduction-provoked pain (increase of 6% vs decrease of 50%). The adverse effects were similar for affected and control upper limbs for all outcomes except arm lymphedema, which occurred only on the affected side.ConclusionsAdverse effects in both affected and control/unaffected upper limb were observed after 2.5-year follow-up in both ALND and SLNB groups, but a higher prevalence was observed in the ALND group. Thus, women going through ALND surgery may benefit from further postoperative physical therapy, including resistance and strength exercise, focusing on pain management.Copyright © 2014 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

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