• J. Infect. Dis. · Jan 2013

    Immunosuppression increases JC polyomavirus large T antigen DNA load in the brains of patients without progressive multifocal leukoencephalopathy.

    • Julianne Bayliss, Tanja Karasoulos, and Catriona A McLean.
    • Department of Medicine, Monash University, Seven, Alfred Centre, Alfred Hospital, Commercial Rd, Melbourne, VIC 3004, Australia. julianne.bayliss@monash.edu
    • J. Infect. Dis. 2013 Jan 1;207(1):133-6.

    AbstractThe relationship between latent JC polyomavirus (JCV) infection and progressive multifocal leukoencephalopathy (PML) remains unclear. In this study, JCV DNA was quantified by real-time polymerase chain reaction (qPCR) in brain and kidney tissue from patients without PML. Immunosuppressed patients had significantly higher JCV DNA levels in brain, compared with immunocompetent patients (P = .001). An inverse relationship was observed between CD4(+) T-cell counts and qPCR-determined brain JCV load among patients with HIV infection (r(2) = -0.9; P = .01; n = 7). Higher kidney JCV DNA load was strongly associated with higher brain JCV DNA load (Spearman ρ = 0.65; P = .004; n = 18). These findings highlight the importance of latent JVC brain infection to the pathogenesis of PML.

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