• Minerva anestesiologica · May 1993

    [Charcoal and isoflurane alveolar washout in low-flow circuit].

    • E Romano, M Pegoraro, A Vacri, C Pecchiari, and E Auci.
    • Istituto Polidisciplinare di Anestesia, Rianimazione e Terapia Antalgica, Università degli Studi di Trieste.
    • Minerva Anestesiol. 1993 May 1;59(5):223-7.

    AbstractThe inclusion of charcoal filters in anaesthetic low-flow systems contributes to the acceleration of the kinetics of isoflurane (Forane). In twenty subjects, scheduled for extra- and intracranial surgery, ventilated with a low-flow system (Ohmeda Excel OAV7750 with rebreathing cassette) with a mean total flow of 0.7 l/min, awakening was complete within 5 minutes from stopping isoflurane and including charcoal in the circuit. At the awakening, the expiratory concentration of isoflurane was 0.23% (95% confidence intervals: 0.19-0.27%): these values are similar to those of MACawake of isoflurane after fast alveolar washout. The use of charcoal during low-flow anaesthesia makes low-flow systems more flexible in their use; the anaesthetic level is more easily controllable and accidental overdosing of volatile anaesthetics can be immediately removed.

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