• Marcio F Chedid, Charles B Rosen, Scott L Nyberg, and Julie K Heimbach.
• Division of Transplantation Surgery, Department of Surgery and William J. von Liebig Transplant Center, Mayo Clinic, Rochester, MN, USA.
• HPB (Oxford). 2014 Sep 1;16(9):852-8.

BackgroundAlthough increasing donor age adversely affects survival after liver transplantation, livers have been used from selected deceased donors older than 70 years. Although there are reports of excellent short-term results, long-term results are unknown. Our experience was reviewed with septuagenarian and octogenarian deceased donors to determine long-term outcomes.MethodsAll primary deceased donor liver transplants performed at our institution between July 1998 and December 2010 were reviewed. Recipients of livers procured after circulatory arrest, split and reduced-size livers and multiple organ transplants were excluded from the study. Patient and graft survival were calculated using the Kaplan-Meier method, and survival comparisons were made with the log-rank test.ResultsIn total, 780 patients met inclusion criteria, and 109 patients received livers from donors older than 70 years (range = 70-86). There were no differences in long-term patient (P = 0.67) or graft (P = 0.42) survival between hepatitis C negative recipients of livers from older compared with younger donors. In contrast, 7-year survival for HCV-positive recipients of older donor livers was less than half that of HCV-negative recipients.DiscussionTransplantation of livers from septua- and octogenarian donors can achieve excellent long-term patient and graft survival for selected HCV-negative patients.© 2014 International Hepato-Pancreato-Biliary Association.

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