• Isabelle Rieu, Philippe Derost, Miguel Ulla, Ana Marques, Bérangère Debilly, Ingrid De Chazeron, Isabelle Chéreau, Jean Jacques Lemaire, Yves Boirie, Pierre Michel Llorca, and Franck Durif.
• CHU Clermont-Ferrand, Neurology Department, Clermont-Ferrand, F-63001, France. irieu@chu-clermontferrand.fr
• J. Neurol. Sci. 2011 Nov 15;310(1-2):267-70.

AbstractDeep brain stimulation (DBS) is a neurosurgical technique that has now been available for some 25 years. It is used in the treatment of various motor disorders, e.g. Parkinson's disease (PD), essential tremor and dystonia, and neuropsychiatric illnesses, e.g. obsessive-compulsive disorder and Tourette syndrome. The surgical targets of DBS include the thalamic ventralis intermedius nucleus (Vim), the globus pallidus internus (GPi) and more recently the subthalamic nucleus (STN), currently considered as the reference target in the treatment of PD. In the last ten years, most studies in PD patients have described a rapid and marked weight gain in the months following DBS of the STN. This weight gain sometimes induces obesity and can have metabolic repercussions. The physiopathological mechanisms responsible for the weight gain are multifactorial (changes in energy metabolism and eating behaviour, reduction of motor complications, etc.). This review reports current knowledge concerning weight changes in patients treated by DBS with different surgical targets. It also describes the mechanisms responsible for weight gain and the health outcome for the patients.Copyright © 2011 Elsevier B.V. All rights reserved.

10 keywords...

hide…