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Pediatr. Infect. Dis. J. · May 2005
Review Comparative StudyDuration of immunity against pertussis after natural infection or vaccination.
- Aaron M Wendelboe, Annelies Van Rie, Stefania Salmaso, and Janet A Englund.
- Department of Epidemiology, University of North Carolina-Chapel Hill, Chapel Hill, NC 27599, USA. awendelboe@unc.edu
- Pediatr. Infect. Dis. J. 2005 May 1;24(5 Suppl):S58-61.
AbstractDespite decades of high vaccination coverage, pertussis has remained endemic and reemerged as a public health problem in many countries in the past 2 decades. Waning of vaccine-induced immunity has been cited as one of the reasons for the observed epidemiologic trend. A review of the published data on duration of immunity reveals estimates that infection-acquired immunity against pertussis disease wanes after 4-20 years and protective immunity after vaccination wanes after 4-12 years. Further research into the rate of waning of vaccine-acquired immunity will help determine the optimal timing and frequency of booster immunizations and their role in pertussis control.
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