• Thorac Cancer · May 2015

    Review

    Current small cell lung cancer treatment in China.

    • Yuankai Shi, Puyuan Xing, Yun Fan, Xin Zhang, Chengping Hu, Caixia Wang, Xiaoqing Liu, Xiaoxia Chen, Jianying Zhou, Mengzhao Wang, Meina Wu, Baohui Han, and Min Fan.
    • Department of Medical Oncology, Cancer Institute/ Hospital, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College (PUMC) Beijing, China ; National Center for Anticancer Drugs Clinical Study Beijing, China ; Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs Beijing, China.
    • Thorac Cancer. 2015 May 1;6(3):233-8.

    BackgroundThe treatment status of small cell lung cancer (SCLC) in Mainland China has never been reported; therefore, this study is the first multicenter survey investigating the status of epidemiology and treatment options of SCLC in Mainland China.MethodsTwo questionnaires were designed to obtain information in 12 medical centers in five major Chinese cities. The hospital information questionnaire was designed to outline SCLC patients' characteristics and treatment preferences in each medical institution, and the patient information questionnaire collected detailed treatment information of 298 SCLC cases in these hospitals.ResultsSCLC represented 13.7% and 18.3% of all lung cancer patients in 2005 and 2010, respectively. Clinical management of SCLC follows mainstream clinical guidelines in general. The most widely applied first-line treatment mode for limited-stage patients was combined chemoradiotherapy (66.2%), while 77.0% of the extensive-stage patients received chemotherapy alone as initial treatment. Etoposide with cisplatin or carboplatin were the most accepted first-line chemotherapy regimens. The objective response rate was 58.3% after first-line chemotherapy and 23% of the patients who responded well to first-line treatment received prophylactic cranial irradiation. As for second-line chemotherapy, single regimen topotecan or a combined regimen containing topotecan were preferred (53.0%).ConclusionsThe treatment options indicated in our study are in accordance with the international clinical guidelines, which is valuable for the improvement of future guidelines, health care standard, and even the better distribution of health care resources in China.

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