• Int. J. Legal Med. · Mar 2007

    Case Reports

    Fatal outcome in a child after ingestion of a transdermal fentanyl patch.

    • Jörg Teske, Jens-Peter Weller, Klaus Larsch, Hans Dieter Tröger, and Matthias Karst.
    • Institute of Legal Medicine, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625, Hannover, Germany. teske.joerg@mh-hannover.de
    • Int. J. Legal Med. 2007 Mar 1;121(2):147-51.

    AbstractThe case history and toxicological findings of a fatal fentanyl intoxication due to ingestion of a transdermal patch are presented. A 1-year-old otherwise healthy girl was put to bed and 2 h later she was found dead. The autopsy revealed a 25-microg/h (4.2 mg) transdermal fentanyl patch in the stomach. Toxicological analysis by liquid chromatography-tandem mass spectrometry with positive electrospray ionization yielded fentanyl and norfentanyl concentrations in the peripheral blood of 5.6 and 5.9 ng/ml, heart blood 19.0 and 8.9 ng/ml, and liver 235 and 26 ng/g, respectively. The cause of death was determined to be a fentanyl overdose. The investigation established that the child has unintentionally swallowed the patch, which had been lying on the floor.

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