• Daniel M Sciubba, Li-Mei Lin, James E Conway, Ali Bydon, Ziya L Gokaslan, and Khaled Kebaish.
• Department of Neurological Surgery, Johns Hopkins University, Baltimore, MD, USA. dsciubb1@jhmi.edu
• Spine. 2007 Nov 15;32(24):E718-22.

Study DesignCase report.ObjectiveTo report a case and review the literature on development of scoliosis following intrathecally placed opioid pump for chronic low back pain.Summary Of Background DataIntrathecal opioid administration is a technique currently indicated for the management of chronic pain syndromes. Despite evidence of scoliosis occurring after baclofen pump insertion, there has been no evidence that development of scoliosis occurs following implantation of an intrathecally placed opioid pump for treatment of lower back pain (LBP).MethodsA retrospective review of patients with adult onset scoliosis was performed at our institution. One patient was identified as showing significant scoliotic progression following implantation of an intrathecally placed opioid pump. Radiographs were analyzed to evaluate the magnitude and configuration of her kyphoscoliosis following pump insertion.ResultsA 50-year-old woman with intractable LBP underwent placement of a spinal cord stimulator (SCS) followed shortly by removal of the SCS and placement of an intrathecal opioid pump. Five years later, she presented with severe kyphoscoliosis involving a left thoracolumbar curve of 84 degrees and sagittal balance of 158 mm. Because of intractable pain and progressive deformity, she underwent multilevel osteotomies, instrumented fusion, and replacement of her Dilaudid pump. Postoperative radiographs demonstrated a residual 23 degrees thoracolumbar curve with restoration of her sagittal alignment. No major morbidity/mortality occurred with treatment.ConclusionAlthough there may not be a direct correlation between implantation of an intrathecal opioid pump with subsequent development of adult onset scoliosis, deformity must be considered a potential sequela in patients treated with such neuromodulation.

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