• Kidney international · Dec 2010

    Comment

    Klotho in acute kidney injury: biomarker, therapy, or a bit of both?

    • Sistiana Aiello and Marina Noris.
    • Transplant Research Center, Chiara Cucchi de Alessandri e Gilberto Crespi, Mario Negri Institute for Pharmacological Research, Ranica, Bergamo, Italy.
    • Kidney Int. 2010 Dec 1;78(12):1208-10.

    AbstractAcute kidney injury (AKI) diagnosis is based on an increase in serum creatinine or a decrease in urine output. To be effective, treatment of AKI should be started very early after the insult and well before the rise of serum creatinine. Thus, sensitive biologic markers of renal tubular injury in AKI are strongly needed. Hu et al. suggest that Klotho could be a novel biomarker and therapeutic target of ischemia-induced AKI.

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